This looks great! I'd love to see a color version. I think my favorite mad scientist is Herbert West. The man can't be stopped, or reasoned with.
Seeing as how we can't technically call Otis Firefly a "mad scientist," although Fishboy was pretty impressive, I guess I'm going to have to go with Mr. Freeze as my favorite mad scientist. He had a singular vision, a larger-than-life chip on his shoulder and an innate understanding to stick to your strength.
Mr Freeze and Herbert West...excellent choices! While I can easily get behind either one as my favorite, I'm rolling with Martin Brundle from Cronenberg's The Fly. I love how he gets into his transformation and is almost gleeful about it at times. A half glass full kinda guy!